A Case Report: Application of 68Ga-PSMA-PET/CT for the Diagnosis of Bone Metastases in Patients with Low Prostate-Specific Antigen Levels

Prostate cancer is the second most common type of cancer in men worldwide. It is one of the 5 most common cancer types and contributes to the greatest number of deaths among male patients. It is most common for prostate cancer to metastasize to the vertebrae, ribs, and pelvis. An important determinant of bone metastasis is the level of prostate-specific membrane antigen (PSMA). The risk of metastatic disease is low in patients who have low serum prostate-specific antigen (PSA) levels. This study examined a patient with suspected bone metastasis based on computed tomography (CT), which is considered to be a rare condition, but whose PSA level was abnormally low. 68Ga-PSMA-PET/CT scans were performed on the patient. It was discovered that bone metastases had developed in several regions of the patients’ body. Several sclerotic lesions were observed in the lumbar vertebrae and bilateral iliac wings, suggesting that bone metastases had occurred. An examination of the pelvis revealed a lesion exhibiting Ga-68 PSMA uptake, with a SUVmax of 4.97. Furthermore, laps with Ga-68 PSMA involvement with SUVmax: 8.65 could also be seen in the paracaval and aortokaval regions.