Key result
In 34 patients with alveolar soft part sarcoma, frequent MRI features included hyperintense T1WI, T2WI, and DWI signals, low ADC, flow voids, and early arterial enhancement.
Why the study?
Alveolar soft part sarcoma is a rare soft tissue sarcoma where early diagnosis is crucial, but its diagnostic imaging features are not well delineated.
Observational (n=34)
ASPS exhibits characteristic MRI features including hyperintense T1WI/T2WI/DWI signals, low ADC, flow voids, and early arterial enhancement, which can aid in early diagnosis.
Background: Alveolar soft part sarcoma (ASPS) is a rare type of soft tissue sarcoma that predominantly affects adolescents and young adults. Early diagnosis of ASPS is crucial for optimal therapeutic planning and improving prognosis, but its diagnostic features are not well delineated. This study aimed to retrospectively analyze the imaging features of ASPS with an emphasis on the dynamic contrast-enhanced-magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) findings to identify imaging findings that might suggest the diagnosis to radiologists. Methods: The imaging features of 34 patients with pathologically proven limb ASPS were retrospectively analyzed. A total of 23 underwent DCE-MRI, and 12 underwent DWI. Results: Among the 34 cases of ASPS, 31 tumors were in the lower extremities, and 3 were in the upper extremities. The maximum tumor diameters ranged from 3.0 to 19.4 cm (mean, 8.7±3.96 cm). A total of 28 cases had well-defined borders. The masses demonstrated heterogeneous high signal intensity on T2-weighted imaging (T2WI) and the fat-suppressed (FS) T2WI sequence and slight hyperintensity on T1-weighted imaging (T1WI). A total of 25 lesions had thin hypointense bands on T1WI and T2WI. Intra- and peri-tumoral tubular areas of flow void were exhibited on both T1WI and T2WI in all cases. A total of 12 cases showed a high signal on DWI, and the mean apparent diffusion coefficient (ADC) value was (0.86±0.07)×10–3 mm2/s [range, (0.6–1.4)×10–3 mm2/s]. Persistent remarkable enhancement of the lesion was displayed on contrast-enhanced scans. The time-intensity curves (TICs) of 23 masses showed early arterial enhancement and slow washout of contrast. Conclusions: ASPS most commonly presents in the lower extremities of adolescents or young adults. Hyperintense T1WI, T2WI, and DWI signals, low ADC, flow voids, early arterial enhancement are frequent MRI features.
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Lv et al. (2023) conducted an observational in Alveolar soft part sarcoma (n=34). DCE-MRI and DWI imaging was evaluated on Imaging features (DCE-MRI and DWI findings). In 34 patients with alveolar soft part sarcoma, frequent MRI features included hyperintense T1WI, T2WI, and DWI signals, low ADC, flow voids, and early arterial enhancement.
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