What question did this study set out to answer?

To evaluate the in vivo metabolic efficacy and therapeutic impact of a prototype hollow fiber liver assist device seeded with hepatocytes in rabbit models of drug metabolism and acute liver failure.

February 1, 1995HepatologyOpen Access

In vivo evaluation of a hollow fiber liver assist device

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Authors

HJHugo O. JaureguiUniversity of Minnesota CMClaudy MullonFresenius Medical Care (United States)DTDonna TrenklerBrown University

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Implication

Animal study demonstrates that a hepatocyte-seeded liver assist device improves survival and detoxification in hepatic failure models, indicating viable potential as a bridge to transplant.

Key Points

To evaluate the in vivo metabolic efficacy and therapeutic impact of a prototype hollow fiber liver assist device seeded with hepatocytes in rabbit models of drug metabolism and acute liver failure.
Tested a prototype hollow fiber extracorporeal liver assist device (LAD) seeded with rabbit hepatocytes in normal rabbits administered diazepam or lidocaine, and in rabbits with galactosamine-induced fulminant hepatic failure.
Administered a 6-hour extracorporeal treatment and evaluated outcomes relative to untreated controls and controls treated with unseeded devices.
Extracorporeal LAD perfusion reduced blood concentrations of diazepam and lidocaine and produced drug metabolites, confirming functional cytochrome P450 activity in the seeded cells.
A 6-hour extracorporeal treatment significantly prolonged survival, delayed the onset of hepatic encephalopathy, and enhanced endogenous hepatocyte regeneration compared to both unseeded and untreated control groups.

Cite This Study

Jauregui et al. (1995) studied this question.

synapsesocial.com/papers/6a7b09ff1ba4614d7ff41d27 https://doi.org/10.1002/hep.1840210230

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Implication

Animal study demonstrates that a hepatocyte-seeded liver assist device improves survival and detoxification in hepatic failure models, indicating viable potential as a bridge to transplant.

In vivo evaluation of a hollow fiber liver assist device

Discussion

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Implication

Key Points

Cite This Study

In vivo evaluation of a hollow fiber liver assist device

Discussion

Member takes

Implication

Key Points

Cite This Study

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