July 14, 2018European Journal of Cardio-Thoracic Surgery
Prognostic implications of psoas muscle area in patients undergoing transcatheter aortic valve implantation
Key result
Psoas muscle area index at the L3 level was independently associated with mortality during follow-up in patients undergoing TAVI (HR 0.200; 95% CI 0.083-0.482; P<0.001).
Why the study?
Does psoas muscle area index predict 30-day and cumulative mortality in patients undergoing TAVI?
Population
1076 consecutive patients undergoing transcatheter aortic valve implantation at 2 centres between 2010 and…
Design
Cohort
Follow-up
median 435 days (interquartile range 139-904)
Authors
Discussion
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Member takes
Implication
Psoas area may refine pre-TAVI mortality risk assessment; extends frailty marker research but leaves open prospective validation.
Study Design
Type
Cohort (n=1,076)
Multicenter
Yes
Structured PICO
Does psoas muscle area index predict 30-day and cumulative mortality in patients undergoing TAVI?
P
Population
1,076 consecutive patients undergoing transcatheter aortic valve implantation, followed for a median of 435 days.
E
Exposure
Computed tomography-derived cross-sectional area of the psoas muscle indexed to body surface area (PMAi)
O
Outcome
30-day and cumulative mortalityhard clinical
Main Result
Hazard Ratio: 0.2 (95% CI 0.083–0.482)
p-value: p=<0.001
Psoas muscle area index is a valuable independent predictor of 30-day and cumulative mortality in patients undergoing TAVI, providing incremental prognostic value over the established STS score.
Cite This Study
Kofler et al. (2018) conducted a cohort in Patients scheduled for transcatheter aortic valve implantation (TAVI) (n=1,076). Psoas muscle area index (PMAi) was evaluated on Mortality during follow-up (HR 0.200, 95% CI 0.083-0.482, p=<0.001). Psoas muscle area index at the L3 level was independently associated with mortality during follow-up in patients undergoing TAVI (HR 0.200; 95% CI 0.083-0.482; P<0.001).