Key result
Six weeks of high-intensity interval training and continuous exercise training attenuated age-related myocardial fibrosis and increased angiogenesis-related molecules in aged rats.
Why the study?
The study aimed to investigate the effect of two different exercise training protocols on myocardial fibrosis and growth factor expression in aged rats.
Does exercise training (HIIT or CET) reduce myocardial fibrosis and increase angiogenesis-related molecules in aged rats?
RCT (n=24)
randomly assigned
Does exercise training (HIIT or CET) reduce myocardial fibrosis and increase angiogenesis-related molecules in aged rats?
Six weeks of HIIT or CET attenuates age-related myocardial fibrosis and increases angiogenesis-related molecules in aged rats.
Both HIIT and CET attenuate myocardial fibrosis in aged rats; leaves open whether benefits translate to older adults.
OBJECTIVES: The present study aimed to investigate the effect of two different exercise training protocols on myocardial fibrosis and the expression of some growth factors in aged rats. METHOD: Twenty-four male Wistar rats were randomly assigned to high-intensity interval training (HIIT) group, continuous exercise training (CET) group, and the control group. After 6 weeks of experiment, mRNA levels of fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), adropin proteins, and myocardial fibrosis were assessed. RESULTS: HIIT and CET induced a significant increase in the FGF-2 and adropin and a decrease in the myocardial fibrosis in compared with the control group. HIIT induced a significant increase in the VEGF if compared with the control group. There was no significant difference between CET and control group. CONCLUSION: Six weeks of HIIT and CET attenuated age-related myocardial fibrosis thereby an increase in angiogenesis-related molecules in cardiac and endothelial tissues.
No takes yet. Share an insight, caveat, or question.
Soori et al. (2019) conducted an RCT in age-related myocardial fibrosis (n=24). High-intensity interval training (HIIT) and continuous exercise training (CET) vs. control group was evaluated on myocardial fibrosis and mRNA levels of FGF-2, VEGF, and adropin proteins. Six weeks of high-intensity interval training and continuous exercise training attenuated age-related myocardial fibrosis and increased angiogenesis-related molecules in aged rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: