Key result
Nitrous oxide maintenance (OR 2.4; 95% CI 1.08-5.32) and use of a tracheal tube (OR 3.0; 95% CI 1.20-7.56) were independently associated with awareness in children.
Why the study?
Are nitrous oxide maintenance and tracheal tube use associated with awareness in children undergoing anaesthesia?
Population
Children undergoing anaesthesia (pooled from 5 cohort studies, n=4486 anaesthetics)
Comparison
Nitrous oxide used as an anaesthetic maintenance… vs No nitrous oxide maintenance and no tracheal tube
Design
Meta-analysis
Authors
Loading...
Suggests caution with nitrous oxide and tracheal tubes in children; extends observational associations but leaves causality open for trials.
Cohort (n=4,486)
Yes
Are nitrous oxide maintenance and tracheal tube use associated with awareness in children undergoing anaesthesia?
Odds Ratio: 2.4 (95% CI 1.08–5.32)
p-value: p=0.03
Nitrous oxide maintenance and tracheal tube use are independent risk factors for awareness in pediatric anesthesia.
Davidson et al. (2011) conducted a cohort in Awareness in paediatric anaesthesia (n=4,486). Nitrous oxide maintenance vs. No nitrous oxide maintenance was evaluated on Awareness (OR 2.4, 95% CI 1.08-5.32, p=0.03). Nitrous oxide maintenance (OR 2.4; 95% CI 1.08-5.32) and use of a tracheal tube (OR 3.0; 95% CI 1.20-7.56) were independently associated with awareness in children.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: