Key result
The Rajan's heart failure risk score demonstrated strong predictive accuracy for HF-related rehospitalization and all-cause mortality (AUC 0.822, p<0.001), outperforming the MAGGIC score (AUC 0.633).
Why the study?
Heart failure with mid-range ejection fraction represents a distinct entity with unique prognostic challenges, lacking widely adopted risk scoring tools for predicting mortality and rehospitalization.
Does the Rajan's heart failure (R-HF) risk score improve prediction of HF-related rehospitalization and all-cause mortality compared to the MAGGIC risk score in patients with HFmrEF?
Cohort (n=175)
Does the Rajan's heart failure (R-HF) risk score improve prediction of HF-related rehospitalization and all-cause mortality compared to the MAGGIC risk score in patients with HFmrEF?
Answers are grounded in this paper and cite their sources.
The Rajan's heart failure risk score demonstrates strong predictive accuracy for mortality and rehospitalization in HFmrEF patients, outperforming the MAGGIC score.
Heart failure with mid-range ejection fraction (HFmrEF) represents a distinct clinical entity with unique prognostic challenges, lacking widely adopted risk scoring tools for predicting mortality and rehospitalization. This study investigates the utility of Rajan’s heart failure (R-HF) risk score as a simple and effective stratification tool in this patient population. In this retrospective cohort study, 175 HFmrEF patients were stratified by R-HF risk score into four groups: high risk, moderate risk, low risk, and minimal risk. The Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk score was calculated for comparison. Receiver operating characteristic (ROC) curve and logistic regression analyses assessed the scores’ predictive performance for a composite endpoint of HF-related rehospitalization and all-cause mortality. The R-HF risk score showed an area under the ROC curve (AUC) of 0.822, suggesting strong predictive accuracy (p < 0.001). An optimal cut-off value of 10.30 achieved a sensitivity of 83.1% and a specificity of 75.0% for predicting HF-related rehospitalization and all-cause mortality. In comparison, the MAGGIC score yielded a lower AUC of 0.633 (p = 0.004). The R-HF risk score effectively stratifies HFmrEF patients by risk, outperforming the frequently used MAGGIC score in this study’s context. Its simplicity and prognostic reliability make it a valuable tool for managing HFmrEF patients, particularly in reducing HF-related rehospitalization and all-cause mortality (Table 4, Fig. 1, Rich in J Am Heart Assoc 7:20 e009594, 2018).
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Pınar Özmen Yıldız (2025) conducted a cohort in Heart failure with mid-range ejection fraction (HFmrEF) (n=175). Rajan's heart failure (R-HF) risk score vs. MAGGIC risk score was evaluated on Composite endpoint of HF-related rehospitalization and all-cause mortality (AUC 0.822, p=<0.001). The Rajan's heart failure risk score demonstrated strong predictive accuracy for HF-related rehospitalization and all-cause mortality (AUC 0.822, p<0.001), outperforming the MAGGIC score (AUC 0.633).
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