Key result
An 81-year-old man developed biopsy-proven anticoagulant-related nephropathy and leukocytoclastic vasculitis while on apixaban therapy, highlighting a rare cause of acute kidney injury.
Why the study?
Anticoagulant-related nephropathy is a cause of acute kidney injury with incompletely understood pathogenetic mechanisms, and oral anticoagulant use has increased leading to reports of adverse effects.
Case Report (n=1)
Answers are grounded in this paper and cite their sources.
Apixaban therapy can be associated with anticoagulant-related nephropathy, presenting as severe acute kidney injury and potentially mimicking systemic vasculitis, particularly in patients with pre-existing chronic kidney disease.
The use of oral anticoagulant drugs has increased in recent years, leading to reports of possible adverse effects. Anticoagulant-related nephropathy (ARN) is a cause of acute kidney injury (AKI) associated with both older and newer anticoagulant agents. The underlying pathogenetic mechanism is not completely understood, but some common risk factors, such as pre-existing renal damage, have been identified. Renal biopsy can help recognize typical but nonspecific lesions. Here, we report the case of a patient with severe renal and systemic involvement while on apixaban therapy.
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Vischini et al. (2023) conducted a case report in Acute kidney injury, anticoagulant-related nephropathy (n=1). Apixaban was evaluated on Development of anticoagulant-related nephropathy. An 81-year-old man developed biopsy-proven anticoagulant-related nephropathy and leukocytoclastic vasculitis while on apixaban therapy, highlighting a rare cause of acute kidney injury.
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