Key result
Dabigatran use in a patient with underlying IgA nephropathy resulted in acute kidney injury due to tubular obstruction by red blood cells and heme-associated tubular injury.
Case Report (n=1)
Dabigatran can cause anticoagulant nephropathy similar to warfarin-related nephropathy, particularly in patients with underlying glomerular disease such as IgA nephropathy.
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Dabigatran may cause anticoagulant nephropathy in IgA nephropathy; hypothesis-generating and should not yet change practice.
Dabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long term anticoagulation. Warfarin-related nephropathy is an increasingly recognized entity, but recent evidence suggests that dabigatran can cause a WRN-like syndrome. We describe a case of a biopsy-proven anticoagulant nephropathy related to dabigatran in a patient with IgA nephropathy and propose that, despite the base glomerular disease, acute kidney injury was due to tubular obstruction by red blood cells and heme-associated tubular injury, and through a mechanism involving inhibition of anticoagulation cascade and barrier abnormalities caused by molecular mechanisms.
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Escoli et al. (2015) conducted a case report in IgA Nephropathy and Dabigatran-Related Nephropathy (n=1). Dabigatran was evaluated on Acute kidney injury / anticoagulant nephropathy. Dabigatran use in a patient with underlying IgA nephropathy resulted in acute kidney injury due to tubular obstruction by red blood cells and heme-associated tubular injury.
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