Key result
Dabigatran can cause anticoagulant-related nephropathy complicated by tubulointerstitial nephritis even in patients with normal baseline renal function, which may respond to corticosteroid therapy.
Case Report (n=1)
No
Dabigatran can cause anticoagulant-related nephropathy even in patients with normal baseline renal function, and underlying conditions like IgA nephropathy or tubulointerstitial nephritis may coexist and respond to corticosteroid therapy.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to monitor for anticoagulant-related nephropathy on dabigatran despite normal baseline function; leaves open the role of corticosteroids pending controlled data.
A 69-year-old woman was referred to our hospital because of an acute kidney injury with macroscopic hematuria. She had been taking dabigatran for atrial flutter for six years. Based on the typical histological findings of her kidney biopsy and her history of dabigatran use with prolonged activated partial thromboplastin time, she was diagnosed with dabigatran-related nephropathy complicated by tubulointerstitial nephritis with IgA nephropathy. After prednisolone therapy, the renal function improved. Direct-acting oral anticoagulants, including dabigatran, may cause anticoagulant-related nephropathy similar to warfarin, even in patients with a normal renal function. Tubulointerstitial nephritis may coexist with dabigatran-related nephropathy, and prednisolone therapy should be considered in such cases. IgA nephropathy has been reported as a background disease, and caution should be exercised when encountering it.
No takes yet. Share an insight, caveat, or question.
Iwafuchi et al. (2023) conducted a case report in Dabigatran-related nephropathy, tubulointerstitial nephritis, IgA nephropathy (n=1). Dabigatran was evaluated. Dabigatran can cause anticoagulant-related nephropathy complicated by tubulointerstitial nephritis even in patients with normal baseline renal function, which may respond to corticosteroid therapy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: