Key result
A literature review on microcirculation in heart failure reveals significant gaps in data regarding microcirculatory changes in chronic heart failure with preserved ejection fraction.
Why the study?
Cardiovascular diseases affect microcirculation to varying degrees, but gaps remain in data on microcirculation changes in chronic heart failure with preserved ejection fraction under modern classification concepts.
This literature review highlights the need for further research on microcirculatory changes specifically in patients with heart failure with preserved ejection fraction (HFpEF).
Answers are grounded in this paper and cite their sources.
Significant data gaps preclude microcirculation assessment in HFpEF; leaves open the need for targeted prospective studies.
Microcirculatory vessels make up about 99% of all vessels in the human body, so cardiovascular diseases at different stages affect microcirculation to varying degrees. The literature review presents studies of different years on microcirculation in heart failure (HF) using the following most popular methods: laser Doppler flowmetry, polarography, nailfold capillaroscopy, bulbar conjunctiva biomicroscopy, and in vitro laboratory tests. Taking into account the changed modern concept of HF and the classification adopted in recent years that assesses the left ventricular ejection fraction, the list of cited works shows gaps in data on microcirculation changes in chronic HF with preserved ejection fraction and prospects for further related research.
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Davidovich et al. (2025) conducted a review in Heart failure. Microcirculation assessment was evaluated. A literature review on microcirculation in heart failure reveals significant gaps in data regarding microcirculatory changes in chronic heart failure with preserved ejection fraction.
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