Key result
Plasma soluble P-selectin concentrations were significantly higher in individuals with the rs1800807 GG genotype and rs1800808 CT/TT genotypes across Han, Uygur, and Kazakh populations (P < 0.05).
Why the study?
The study sought to investigate the relationship of P-selectin gene rs1800807 and rs1800808 polymorphisms with plasma soluble P-selectin in Han, Uygur, and Kazakh individuals with AF and thromboembolism in Xinjiang, China.
Observational (n=1,943)
No
p-value: p=<0.05
P-selectin gene polymorphisms rs1800807 and rs1800808 are associated with plasma soluble P-selectin concentrations, with variations observed among Han, Uygur, and Kazakh populations with atrial fibrillation.
Ethnic variants in P-selectin may refine AF-related TE risk models; leaves open prospective validation before clinical adoption.
This study is to investigate the relationship of P-selectin (Ps) gene rs1800807 and rs1800808 polymorphisms with plasma soluble P-selectin (sPs) in Han, Uygur, and Kazakh people with atrial fibrillation (AF) and thromboembolism (TE) in Xinjiang, China.A total of 778 Han patients (including 131 patients with AF and TE, 229 patients with AF and 418 healthy individuals), 660 Uygur patients (including 118 patients with AF and TE, 232 patients with AF and 310 healthy individuals), and 505 Kazakh patients (including 42 patients with AF and TE, 156 patients with AF and 307 healthy individuals) were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism and direct DNA sequence analysis were used to analyze the polymorphisms of rs1800807 and rs1800808 of Ps gene. ELISA was used to determine the plasma sPs level. The association between plasma sPs levels and Ps gene polymorphisms was further analyzed.The sPs concentrations of GG genotype at rs1800807 locus in the Han, Uygur and Kazakh ethnic groups in Xinjiang, China were significantly higher than those of the CC genotype and CG genotype (P < .05). In the rs1800808 locus, plasma sPs concentrations of the heterozygous mutant CT genotypes in Han and Uygur populations were significantly higher than those in the CC and TT genotypes, whereas the plasma sPs concentrations in Kazakh TT genotypes were significantly higher than those in the CC and CT genotypes (P < .05). Among different ethnic groups, there were significant differences in sPs levels of rs1800807 and rs1800808 genotypes (P < .05).Plasma sPs concentrations are associated with Ps genotypes and sPs concentration of the same genotype shows racial differences.
No takes yet. Share an insight, caveat, or question.
Ma et al. (2020) conducted an observational in Atrial fibrillation complicated with thromboembolism (n=1,943). P-selectin gene rs1800807 and rs1800808 polymorphisms vs. Wild-type genotypes was evaluated on Plasma soluble P-selectin (sPs) concentration (p=<0.05). Plasma soluble P-selectin concentrations were significantly higher in individuals with the rs1800807 GG genotype and rs1800808 CT/TT genotypes across Han, Uygur, and Kazakh populations (P < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: