Key result
Bibliometric analysis of 1,069 articles from 2004 to 2022 identified China and the United States as leading contributors, with emerging research hotspots including cell death, exosomes, intestinal flora, and anesthetics in intestinal ischemia/reperfusion injury.
Why the study?
Intestinal ischemia/reperfusion injury is common in surgical practice, but a comprehensive bibliometric review of research collaboration, impact, knowledge structure evolution, and emerging trends was needed.
This bibliometric analysis maps the knowledge structure and research trends in intestinal ischemia/reperfusion injury, highlighting cell death, exosomes, intestinal flora, and anesthetics as current focuses.
Bibliometric trends map emerging foci in intestinal ischemia/reperfusion injury; leaves open clinical translation pending prospective trials.
Background: Intestinal ischemia/reperfusion (I/R) injury is a common tissue-organ damage occurring in surgical practice. This study aims to comprehensively review the collaboration and impact of countries, institutions, authors, subject areas, journals, keywords, and critical literature on intestinal I/R injury from a bibliometric perspective, and to assess the evolution of clustering of knowledge structures and identify hot trends and emerging topics. Methods: Articles and reviews related to intestinal I/R were retrieved through subject search from Web of Science Core Collection. Bibliometric analyses were conducted on Excel 365, CiteSpace, VOSviewer, and Bibliometrix (R-Tool of R-Studio). Results: A total of 1069 articles and reviews were included from 2004 to 2022. The number of articles on intestinal I/R injury gradually plateaued, but the number of citations increased. These publications were mainly from 985 institutions in 46 countries, led by China and the United States. Liu Kx published the most papers, while Chiu Cj had the largest number of co-citations. Analysis of the journals with the most outputs showed that most journals focused on surgical sciences, cell biology, and immunology. Macroscopic sketch and microscopic characterization of the entire knowledge domain were achieved through co-citation analysis. The roles of cell death, exosomes, intestinal flora, and anesthetics in intestinal I/R injury are the current and developing research focuses. The keywords "dexmedetomidine", "proliferation", and "ferroptosis" may also become new trends and focus of future research. Conclusion: This study comprehensively reviews the research on intestinal I/R injury using bibliometric and visualization methods, and will help scholars better understand the dynamic evolution of intestinal I/R injury and provide directions for future research.
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Wan et al. (2022) studied Intestinal ischemia/reperfusion injury (n=1,069). Bibliometric and visual analysis was evaluated on Bibliometric trends including publication output, citations, and research hotspots. Bibliometric analysis of 1,069 articles from 2004 to 2022 identified China and the United States as leading contributors, with emerging research hotspots including cell death, exosomes, intestinal flora, and anesthetics in intestinal ischemia/reperfusion injury.
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