What question did this study set out to answer?

To measure serum concentrations of total and free thyroxine and triiodothyronine in healthy pregnancies and pregnancies complicated by pre-eclampsia or gestational trophoblastic disease.

January 1, 1976The Journal of Clinical Endocrinology & Metabolism

Total and Free Thyroxine and Triiodothyronine in Normal and Complicated Pregnancy

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To measure serum concentrations of total and free thyroxine and triiodothyronine in healthy pregnancies and pregnancies complicated by pre-eclampsia or gestational trophoblastic disease.
Measured serum total thyroxine (T4), free thyroxine (FT4), total triiodothyronine (T3), and free triiodothyronine (FT3) across cohorts.
Compared healthy pregnant women to patients presenting with pre-eclampsia (n=9 evaluated for FT3) and gestational trophoblastic disease (GTD) with or without clinical hyperthyroidism.
In pre-eclampsia, mean serum T4 and FT4 were significantly higher than in normal pregnancy, whereas mean T3 was significantly lower, with FT3 falling below normal pregnancy ranges in 3 of 9 patients.
In GTD patients without hyperthyroidism, mean total and free T4 concentrations were 43% and 92% higher than in normal pregnancy (P < 0.02), whereas total and free T3 levels did not differ significantly.
A patient with GTD and hyperthyroid crisis exhibited marked elevations in serum FT3 compared to normal pregnancy and non-hyperthyroid GTD, while FT4 remained within the non-hyperthyroid GTD range.

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Implication

Observational study reveals distinct thyroid hormone alterations in pre-eclampsia and trophoblastic disease, indicating altered peripheral hormone metabolism.

Cite This Study

Osathanondh et al. (1976) studied this question.

synapsesocial.com/papers/6a7b283d14b028facf0eb3ae https://doi.org/10.1210/jcem-42-1-98

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Implication

Observational study reveals distinct thyroid hormone alterations in pre-eclampsia and trophoblastic disease, indicating altered peripheral hormone metabolism.

Total and Free Thyroxine and Triiodothyronine in Normal and Complicated Pregnancy

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Discussion

Implication

Cite This Study

Total and Free Thyroxine and Triiodothyronine in Normal and Complicated Pregnancy

Key Points

Discussion

Implication

Cite This Study

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