Key result
Three cases of peripartum dilated cardiomyopathy associated with hypomagnesaemia are presented, highlighting a potential link between magnesium deficiency and heart failure in pregnancy.
Why the study?
Dilated cardiomyopathy in pregnancy carries significant maternal morbidity and mortality, while pregnancy induces a physiological fall in serum magnesium and hypomagnesaemia is linked to adverse cardiac outcomes.
Case Report (n=3)
Highlights a potential association between magnesium deficiency and the development of peripartum dilated cardiomyopathy, suggesting a need for further research.
These cases suggest hypomagnesaemia may associate with peripartum cardiomyopathy; leaves open causal role and need for prospective studies.
Dilated cardiomyopathy in pregnancy, whether diagnosed pre-conception, or occurring de novo during pregnancy, may be associated with significant maternal morbidity and mortality. Hypomagnesaemia is associated with ventricular arrhythmias and may be a risk factor for heart failure, coronary artery disease and atrial fibrillation in the general population. Pregnancy is associated with a progressive physiological fall in serum magnesium concentration. Intracellular magnesium deficiency may exist despite normal serum magnesium concentration. Three cases of dilated cardiomyopathy developing in the peripartum period with hypomagnesaemia are presented. The literature regarding associations between magnesium deficiency and dilated cardiomyopathy is reviewed. Potential future research examining magnesium deficiency as a potential contributor to dilated cardiomyopathy in pregnancy is proposed, and possible implications for management are discussed.
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Adam Morton (2025) conducted a case report in Dilated cardiomyopathy in the peripartum period (n=3). Magnesium deficiency / Hypomagnesaemia was evaluated. Three cases of peripartum dilated cardiomyopathy associated with hypomagnesaemia are presented, highlighting a potential link between magnesium deficiency and heart failure in pregnancy.
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