Why the study?
Does levosimendan improve hemodynamics and regional blood flow in a porcine model of endotoxemia?
Population
14 landrace pigs in a porcine model of endotoxemia
Comparison
Levosimendan given as a bolus followed by a… vs Control group receiving endotoxin without…
Design
Preclinical
Follow-up
3 hours
Authors
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Hypothesis-generating in porcine endotoxemia; leaves open clinical translation pending human trials.
Does levosimendan improve hemodynamics and regional blood flow in a porcine model of endotoxemia?
In a porcine model of endotoxin shock, pretreatment with levosimendan improved cardiac output, systemic and gut oxygen delivery, and attenuated pulmonary hypertension.
Oldner et al. (2001) studied this question.
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