March 4, 1997Circulation
Sexually Dimorphic Response of the Balloon-Injured Rat Carotid Artery to Hormone Treatment
Why the study?
Does 17 beta-estradiol and/or medroxyprogesterone acetate alter the neointimal response in balloon-injured carotid arteries of intact male and female rats?
Population
Intact male and female Sprague-Dawley rats subjected to balloon injury of the right common carotid artery
Comparison
17 beta-estradiol, medroxyprogesterone acetate… vs Vehicle
Design
Preclinical, randomly divided
Follow-up
2 weeks
Authors
Discussion
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Implication
Sex-specific estrogen-MPA interactions in rat vascular injury; leaves open translation to human restenosis or hormone therapy effects.
Structured PICO
Does 17 beta-estradiol and/or medroxyprogesterone acetate alter the neointimal response in balloon-injured carotid arteries of intact male and female rats?
P
Population
Intact male and female Sprague-Dawley rats subjected to balloon injury of the right common carotid artery
I
Intervention
17 beta-estradiol, medroxyprogesterone acetate (MPA), or 17 beta-estradiol + MPA
C
Comparator
Vehicle
O
Outcome
Myointimal thickening of the carotid arteriessurrogate
Exogenous estrogen blunts the neointimal response to vascular injury in intact female but not male rats, and this vasoprotective effect is blocked by the addition of a progestin.
Cite This Study
Oparil et al. (1997) studied this question.