The Odyssey of TAVR from Concept to Clinical Reality
Key result
Transcatheter aortic valve replacement has evolved over 20 years into a validated alternative to surgical replacement for severe aortic stenosis, demonstrating a 20% absolute increase in 1-year survival versus medical therapy in inoperable patients.
Population
Patients with severe calcific aortic stenosis, particularly those considered inoperable or at high risk for…
Design
Review
Authors
Discussion
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Implication
Supports TAVR in inoperable severe aortic stenosis; extends historical validation for prospective durability and expansion trials.
Structured PICO
P
Population
Patients with severe calcific aortic stenosis, particularly those considered inoperable or at high risk for surgical aortic valve replacement.
I
Intervention
Transcatheter aortic valve replacement (TAVR) / percutaneous implantation of an aortic valve bioprosthesis
This historical review chronicles the development of TAVR from a conceptual idea to a revolutionary, globally adopted treatment for severe aortic stenosis.
Limitations
- Long-term durability of the transcatheter heart valve has not been fully established
Cite This Study
Alain Cribier (2014) conducted a review in Aortic stenosis. Transcatheter Aortic Valve Replacement (TAVR) vs. Surgical Aortic Valve Replacement (SAVR) or medical therapy was evaluated. Transcatheter aortic valve replacement has evolved over 20 years into a validated alternative to surgical replacement for severe aortic stenosis, demonstrating a 20% absolute increase in 1-year survival versus medical therapy in inoperable patients.