Key result
Moderate and moderate-to-severe paravalvular aortic regurgitation after TAVI was associated with increased 1-year cardiovascular mortality compared to no or mild PAR (73% vs. 7%, p<0.001).
Why the study?
Does moderate to severe paravalvular aortic regurgitation after TAVI increase cardiovascular mortality in patients undergoing TAVI?
Population
167 consecutive patients undergoing transcatheter aortic valve implantation (TAVI)
Comparison
Moderate and moderate-to-severe paravalvular… vs No or mild paravalvular aortic regurgitation…
Design
Cohort
Follow-up
1 year
Authors
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Supports vigilant post-TAVI PAR monitoring; leaves open whether reducing moderate regurgitation improves survival.
Cohort (n=167)
Does moderate to severe paravalvular aortic regurgitation after TAVI increase cardiovascular mortality in patients undergoing TAVI?
Absolute Event Rate: 73% vs 7%
p-value: p=<0.001
Moderate to severe paravalvular aortic regurgitation after TAVI is associated with significantly increased cardiovascular mortality, and a post-procedural diastolic pressure gradient (∆PDAP-LVEDP) ≤18 mmHg is a strong predictor of adverse outcomes.
Patsalis et al. (2013) conducted a cohort in Transcatheter aortic valve implantation (TAVI) (n=167). Moderate and moderate-to-severe paravalvular aortic regurgitation (PAR) vs. No and mild PAR was evaluated on Cardiovascular mortality at one year (p=<0.001). Moderate and moderate-to-severe paravalvular aortic regurgitation after TAVI was associated with increased 1-year cardiovascular mortality compared to no or mild PAR (73% vs. 7%, p<0.001).
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