Key result
In patients with Graves' disease aged 45 and older, the GG genotype of the KCNE1 Ser38Gly polymorphism was associated with a significantly higher prevalence of atrial fibrillation compared to AG and AA genotypes (35.3% vs 13.9%).
Why the study?
Is the Ser38Gly polymorphism in the KCNE1 gene associated with atrial fibrillation and cardiac remodeling in patients with Graves' disease?
Case-Control (n=342)
No
Is the Ser38Gly polymorphism in the KCNE1 gene associated with atrial fibrillation and cardiac remodeling in patients with Graves' disease?
The Ser38Gly polymorphism in the KCNE1 gene is associated with a higher prevalence of atrial fibrillation in patients with Graves' disease aged 45 and older, though its influence is secondary to traditional risk factors.
Answers are grounded in this paper and cite their sources.
May support AF risk stratification in older Graves' patients; hypothesis-generating and should not yet change practice.
The relevance of the research. The risk factors of developing severe thyrotoxic cardiomyopathy (TCMP) are not certainly determined now. But it is essential to choose the optimal approach to care. Recent studies show that even patients of the same sex, with similar age, duration of thyrotoxicosis and hormones’ level differ in a severity of cardiomyopathy. So, scientists began to search for genetic risk predictors of the heart damage, caused by thyrotoxicosis. Among possible genetic predictors of thyrotoxicosis are single nucleotide polymorphisms in genes, that expression is regulated by thyroid hormones or genes, that are involved in developing of non-thyrotoxic cardiac pathology. Aim. To investigate the possible association of the polymorphism Ser38Gly in KCNE1 gene with different manifestations of thyrotoxic cardiomyopathy, especially with atrial fibrillation and cardiac remodeling. Materials and methods. 155 patients with thyrotoxicosis caused by Graves’ disease were enrolled. Genotyping was also made in 187 healthy blood donors – the control group. Genotyping was performed by real time polymerase chain reaction. Results. Our results show an interaction of the single nucleotide polymorphism Ser38Gly in KCNE1 gene with TCMP only in patients aged 45 and older. In this age group atrial fibrillation was significantly more prevalent in GG genotype carriers: 35.3% (GG) vs 13.9% (AG+AA) ( p = 0.037). Also, there was a significant difference in systolic blood pressure (SBP) by KCNE1 codon 38 genotypes. SBP were significantly higher in allele G gomozygotes as compared to allele A carriers: 124.89 ± 15.14 mm Hg vs 131.35 ± 15.32 mm Hg ( p = 0.012). Conclusion. The fact, that association of the polymorphism Ser38Gly with atrial fibrillation was shown only in group with patients older than 45 years, proves that its influence is of a lower value in comparison with “traditional” risk factors. There was no significant difference among genotypes in severity of TCMP and types of myocardial re-modeling.
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Babenko et al. (2015) conducted a case-control in Graves' disease with manifest thyrotoxicosis (n=342). Ser38Gly polymorphism in the KCNE1 gene (GG genotype) vs. AG and AA genotypes was evaluated on Prevalence of atrial fibrillation in patients aged 45 and older (p=0.037). In patients with Graves' disease aged 45 and older, the GG genotype of the KCNE1 Ser38Gly polymorphism was associated with a significantly higher prevalence of atrial fibrillation compared to AG and AA genotypes (35.3% vs 13.9%).
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