Answers are grounded in this paper and cite their sources.
Hypotheses in large-scale clinical trials with high levels of evidence that affect clinical care guidelines are rarely developed from scratch. Rather, hypotheses from numerous small studies that tinker with processes from clinical experience or from modest research ideas are developed, tested, and discarded at varying stages of research and evidence levels. 1) During these processes, some ideas attract attention from academic societies, policymakers, or industries and survive for inclusion in larger trials.
No takes yet. Share an insight, caveat, or question.
Jung et al. (2019) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: