Key result
Short-term endurance exercise training protected against doxorubicin-induced increases of FoxO1 and MuRF-1 in cardiac muscle and prevented the rise of FoxO3, MuRF-1, and BNIP3 in soleus muscle.
Why the study?
Does short-term endurance exercise training prevent acute doxorubicin-induced FoxO transcription of atrophy genes in cardiac and skeletal muscle in rats?
Does short-term endurance exercise training prevent acute doxorubicin-induced FoxO transcription of atrophy genes in cardiac and skeletal muscle in rats?
p-value: p=<0.05
Short-term endurance exercise training protects against acute doxorubicin-induced myopathy in cardiac and skeletal muscle by upregulating PGC-1α and suppressing FoxO-mediated transcription of atrophy genes.
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Hypothesis-generating for exercise preconditioning in doxorubicin myopathy; does not yet inform clinical practice.
Kavazis et al. (2014) studied Doxorubicin-induced myopathy (n=24). Short-term endurance exercise training vs. Sedentary control was evaluated on FoxO1 and FoxO3 mRNA expression and transcription of FoxO target genes (p=<0.05). Short-term endurance exercise training protected against doxorubicin-induced increases of FoxO1 and MuRF-1 in cardiac muscle and prevented the rise of FoxO3, MuRF-1, and BNIP3 in soleus muscle.
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