Key result
Mild hypothermic cardiopulmonary bypass was associated with a significantly higher postoperative De Ritis ratio compared to normothermic bypass (3.12 vs 2.89, p=0.048), indicating greater hepatic stress.
Why the study?
To comparatively evaluate the effects of normothermic and mild hypothermic cardiopulmonary bypass strategies on liver function in CABG operations through De Ritis ratio dynamics.
Does normothermic cardiopulmonary bypass reduce hepatic injury as measured by the De Ritis ratio compared to mild hypothermic cardiopulmonary bypass in patients undergoing CABG?
Cross-Sectional (n=150)
No
Does normothermic cardiopulmonary bypass reduce hepatic injury as measured by the De Ritis ratio compared to mild hypothermic cardiopulmonary bypass in patients undergoing CABG?
Normothermic cardiopulmonary bypass is associated with lower De Ritis ratios compared to mild hypothermia, suggesting a hepatoprotective benefit during coronary artery bypass grafting.
Normothermic CPB was associated with lower De Ritis ratios in CABG; hypothesis-generating for liver protection and requires prospective validation.
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Reşat Dikme (2025) conducted a cross-sectional in Coronary artery bypass grafting (CABG) (n=150). Mild hypothermic cardiopulmonary bypass vs. Normothermic cardiopulmonary bypass was evaluated on De Ritis ratio (AST/ALT) in the postoperative period (p=0.048). Mild hypothermic cardiopulmonary bypass was associated with a significantly higher postoperative De Ritis ratio compared to normothermic bypass (3.12 vs 2.89, p=0.048), indicating greater hepatic stress.
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