Key result
Continuous administration of cisplatin significantly altered renal function markers including BUN, creatinine, and sodium excretion in rats, with BUN and creatinine alterations being gender-dependent.
Why the study?
Does cisplatin dosing protocol and gender affect renal function and sodium excretion in rats?
Does cisplatin dosing protocol and gender affect renal function and sodium excretion in rats?
p-value: p=<0.05
Cisplatin-induced nephrotoxicity in rats is dependent on both the dosing protocol and gender.
Rat findings on gender- and protocol-specific cisplatin nephrotoxicity warrant clinical caution; leaves open human validation.
Background: Nephrotoxicity is one of the side effects of cisplatin (CP) therapy which is gender related. CP disturbs renal function through glomerular filtration rate and electrolytes transport disturbances. This study was designed to compare some markers related to renal function in two protocols of CP treatment in rats. Materials and Methods: Male and female rats were subjected to receive single (treat 1; 7.5 mg/kg) and continues doses (treat 2; 3 mg/kg/day for 5 days) of CP, and the measurements were compared with control animals. Results: The serum level of blood urea nitrogen (BUN) and creatinine (Cr), and Cr-clearance, kidney tissue damage score, kidney weight, body weight change, and Na excretion was altered significantly ( P < 0.05) in animals treated with continuous dose of CP (treat 2), while alteration of BUN and Cr was gender related. The kidney levels of malondialdehyde and nitrite were significantly different between male and female in two protocols of treatments. Conclusion: Renal function after CP therapy alters in rats’ gender dependently, and it is related to protocol of treatment.
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Jilanchi et al. (2018) studied Cisplatin-induced nephrotoxicity (n=44). Cisplatin vs. Saline (vehicle) was evaluated on Renal function markers (BUN, Cr, Cr-clearance, KTDS, kidney weight, body weight change, Na excretion) (p=<0.05). Continuous administration of cisplatin significantly altered renal function markers including BUN, creatinine, and sodium excretion in rats, with BUN and creatinine alterations being gender-dependent.
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