Key result
Cisplatin induces greater nephrotoxicity in male rats compared to females.
Why the study?
The role of gender in cisplatin-induced nephrotoxicity and hepatotoxicity was investigated due to known side effects of cisplatin therapy.
Does gender affect the severity of cisplatin-induced nephrotoxicity in a rat model?
Does gender affect the severity of cisplatin-induced nephrotoxicity in a rat model?
p-value: p=<0.05
In a rat model, cisplatin-induced nephrotoxicity is more severe in males than in females, suggesting a gender-related mechanism of damage.
May signal greater male susceptibility to cisplatin nephrotoxicity; leaves open confirmation in patients and any dosing implications.
BACKGROUND: Nephrotoxicity and hepatotoxicity are side effects of Cisplatin (CP) therapy. OBJECTIVES: We investigated the role of gender in CP-induced nephrotoxicity and hepatotoxicity. MATERIALS AND METHODS: Low dose of CP (1 mg/kg/day; ip) was administered daily to male and female Wistar rats for 15 consecutive days. Serum creatinine (Cr), blood urea nitrogen (BUN), malondialdehyde (MDA), nitric oxide (NO) metabolite, and magnesium (Mg) levels were determined. RESULTS: The percentage of weight loss and the serum levels of MDA and nitrite in male and female animals were not statistically different. However, the serum levels of BUN, Cr, Mg, and kidney MDA levels, and kidney weight and damage score were significantly greater in males than in females (P < 0.05). CONCLUSIONS: CP-induced nephrotoxicity is gender related for which the mechanisms should be determined.
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Nematbakhsh et al. (2013) studied Cisplatin-induced nephrotoxicity (n=15). Cisplatin vs. Female rats (compared to male rats) was evaluated on Serum levels of BUN, Cr, Mg, kidney MDA, kidney weight, and damage score (p=<0.05). Male rats treated with cisplatin developed significantly greater nephrotoxicity compared to female rats, indicated by higher BUN, creatinine, magnesium, and kidney damage scores (P < 0.05).
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