Key result
Initiation of cholinesterase inhibitor therapy in older adults was associated with a more than doubling of the risk of hospitalization for bradycardia (adjusted OR 2.13).
Why the study?
Does the initiation of cholinesterase inhibitors increase the risk of hospitalization for bradycardia in older adults?
Case-Control (n=627)
Does the initiation of cholinesterase inhibitors increase the risk of hospitalization for bradycardia in older adults?
Odds Ratio: 2.13 (95% CI 1.29–3.51)
p-value: p=0.003
Initiation of cholinesterase inhibitors in older adults is associated with a more than two-fold increased risk of hospitalization for bradycardia, a potentially severe adverse event that appears underappreciated by clinicians.
No takes yet. Share an insight, caveat, or question.
May warrant caution with cholinesterase inhibitor initiation in older adults; leaves open need for prospective confirmation.
Park‐Wyllie et al. (2009) conducted a case-control in Dementia (users of cholinesterase inhibitors) (n=627). Cholinesterase inhibitors vs. Reference interval (months 7-9 prior to index date) / Control patients was evaluated on Hospitalization for bradycardia (OR 2.13, 95% CI 1.29-3.51, p=0.003). Initiation of cholinesterase inhibitor therapy in older adults was associated with a more than doubling of the risk of hospitalization for bradycardia (adjusted OR 2.13).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: