Key result
Treatment with 100,000 IU of vitamin D3 monthly for 3 months did not significantly improve brachial artery flow-mediated dilatation in obese adolescents (10.3% vs baseline 9.5%, P=0.83).
Why the study?
Does vitamin D3 improve endothelial function in obese adolescents with vitamin D deficiency?
Does vitamin D3 improve endothelial function in obese adolescents with vitamin D deficiency?
Absolute Event Rate: 10.3% vs 9.5%
p-value: p=0.83
High-dose vitamin D3 supplementation effectively raises serum 25(OH)D levels but does not improve endothelial function in obese adolescents.
Should not yet change practice for endothelial function in obese adolescents; hypothesis-generating for vitamin D effects on vascular health.
BACKGROUND: Obesity in children is associated with vitamin D deficiency and endothelial dysfunction. It is not known if treatment with vitamin D improves endothelial function in obese adolescents. OBJECTIVE: This study aimed to determine whether treatment with vitamin D3 improves endothelial function in obese adolescents. METHODS: Nineteen obese adolescents, 13-18 years of age, with 25-hydroxy vitamin D (25[OH]D) levels <75 nmol L(-1) were treated with 100 000 IU vitamin D3 orally once a month for 3 months in an open-label, single-centre prospective trial. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at study entry and 1 month after the third dose of vitamin D3 . Biochemical parameters, including calcium, fasting lipids, glucose, insulin and high-sensitivity C-reactive protein, were also obtained. RESULTS: Mean 25(OH)D levels increased from 55.9 ± 12.2 to 86.9 ± 16.7 nmol L(-1) (P < 0.01). There was no correlation between 25(OH)D levels and brachial artery FMD. The brachial artery FMD (%) did not change significantly following vitamin D3 treatment (9.5 ± 3.53 vs. 10.3 ± 3.83, P = 0.83). Serum parathyroid hormone declined from 3.8 ± 1.5 to 3.1 ± 1 pmol L(-1) (P = 0.01). The remainder of biochemical measurements did not show a significant change. CONCLUSIONS: Treatment with vitamin D3 , 100 000 IU once a month for 3 months was effective in increasing 25(OH)D levels in obese adolescents but did not impact endothelial function.
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Javed et al. (2015) studied Obesity with vitamin D deficiency (n=19). Vitamin D3 vs. Baseline was evaluated on Brachial artery flow-mediated dilatation (FMD) (p=0.83). Treatment with 100,000 IU of vitamin D3 monthly for 3 months did not significantly improve brachial artery flow-mediated dilatation in obese adolescents (10.3% vs baseline 9.5%, P=0.83).
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