Key result
Ginsenoside Rg3 demonstrates broad antioxidant and anti-inflammatory effects in preclinical models, indicating its potential as a therapeutic agent for various acute and chronic diseases.
Why the study?
Inflammation and oxidative stress contribute to multiple acute and chronic diseases, and ginsenoside Rg3 has demonstrated diverse antioxidant and anti-inflammatory properties across disease models.
Preclinical evidence suggests ginsenoside Rg3 is a promising candidate for treating diseases characterized by inflammatory and oxidative stress conditions.
No clinical use of ginsenoside Rg3 yet; leaves open translation to human inflammatory disease trials.
Inflammation and oxidative stress lead to various acute or chronic diseases, including pneumonia, liver and kidney injury, cardiovascular and cerebrovascular diseases, metabolic diseases, and cancer. Ginseng is a well-known and widely used ethnic medicine in Asian countries, and ginsenoside Rg3 is a saponin isolated from Panax ginseng C. A. Meyer, Panax notoginseng, or Panax quinquefolius L. This compound has a wide range of pharmacological properties, including antioxidant and anti-inflammatory activities, which have been evaluated in disease models of inflammation and oxidative stress. Rg3 can attenuate lung inflammation, prevent liver and kidney function damage, mitigate neuroinflammation, prevent cerebral and myocardial ischemia–reperfusion injury, and improve hypertension and diabetes symptoms. The multitarget, multipathway mechanisms of action of Rg3 have been gradually deciphered. This review summarizes the existing knowledge on the anti-inflammatory and antioxidant effects and underlying molecular mechanisms of ginsenoside Rg3, suggesting that ginsenoside Rg3 may be a promising candidate drug for the treatment of diseases with inflammatory and oxidative stress conditions.
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Wang et al. (2022) conducted a review in Inflammation and oxidative stress-related diseases. Ginsenoside Rg3 was evaluated. Ginsenoside Rg3 demonstrates broad antioxidant and anti-inflammatory effects in preclinical models, indicating its potential as a therapeutic agent for various acute and chronic diseases.
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