Key result
Vascular density in the superficial and deep capillary plexuses progressively decreased across more advanced stages of diabetic retinopathy compared to normal subjects (p<0.001).
Why the study?
The study was conducted to determine discrepancies in quantitative measurements of retinal and choriocapillaris vascular density across diabetic retinopathy stages using SD OCTA compared with normal subjects.
Does quantitative measurement of retinal and choriocapillaris vascular density using OCTA differ between diabetic retinopathy stages and normal subjects?
Cross-Sectional (n=97)
No
Does quantitative measurement of retinal and choriocapillaris vascular density using OCTA differ between diabetic retinopathy stages and normal subjects?
p-value: p=<0.001
Retinal vascular density changes measured by OCTA serve as a potential biomarker for diabetic retinopathy development before it becomes clinically evident.
No takes yet. Share an insight, caveat, or question.
Should not yet change diabetic retinopathy management; leaves open OCTA vascular density as a progression biomarker pending longitudinal data.
Ghassemi et al. (2020) conducted a cross-sectional in Diabetic retinopathy (n=97). Diabetic retinopathy stages (NDR, NPDR, PDR) vs. Normal subjects was evaluated on Vascular density (VD) in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) (p=<0.001). Vascular density in the superficial and deep capillary plexuses progressively decreased across more advanced stages of diabetic retinopathy compared to normal subjects (p<0.001).
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