What question did this study set out to answer?

To investigate the role and molecular mechanisms of vitamin A metabolites in the conversion of naive CD4+ T cells into FoxP3+ regulatory T cells.

September 1, 2007The Journal of Immunology

Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

View Full Paper

Ask AI

Bookmark

Authors

SKSeung Goo KangKangwon National University HLHyung W. LimGladstone Institutes OAOurania AndrisaniPurdue University West Lafayette

Discussion

Member takes

Implication

Preclinical study reveals that retinoic acid induces gut-homing FoxP3+ regulatory T cells in human and mouse models, suggesting a key dietary role in intestinal immune tolerance.

Key Points

To investigate the role and molecular mechanisms of vitamin A metabolites in the conversion of naive CD4+ T cells into FoxP3+ regulatory T cells.
Assessed human and mouse naive FoxP3- CD4+ T cell differentiation following exposure to all-trans-retinoic acid alongside mucosal dendritic cell activation and CD28 costimulation.
Analyzed FoxP3 promoter histone acetylation, suppressive function, gut-homing receptor expression, and reciprocal regulation against inflammatory Th17 cell differentiation pathways.
All-trans-retinoic acid promoted FoxP3 promoter histone acetylation and FoxP3 protein expression via nuclear retinoic acid receptor alpha in human and mouse T cells.
Retinoic acid enhanced TGF-beta1-dependent generation of functional FoxP3+ regulatory T cells while suppressing TGF-beta1- and IL-6-dependent generation of inflammatory Th17 cells in mouse T cells.
Induced regulatory T cells demonstrated potent target cell suppression and high expression of gut-homing receptors mediating migration to the small intestine.

Cite This Study

Kang et al. (2007) studied this question.

synapsesocial.com/papers/6a7b6995bdf697b3de02f419 https://doi.org/10.4049/jimmunol.179.6.3724

View Full Paper

Ask AI

Bookmark

Implication

Preclinical study reveals that retinoic acid induces gut-homing FoxP3+ regulatory T cells in human and mouse models, suggesting a key dietary role in intestinal immune tolerance.

Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider