Why the study?
Does angiotensin (1-7) improve impulse conduction and membrane potential in ischaemic rat heart muscle?
Population
Adult rat hearts subjected to 40 minutes of global no-flow ischaemia followed by reperfusion
Comparison
Angiotensin (1-7) (10-8 M) vs Baseline conditions and co-administration with…
Design
Preclinical
Authors
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May support Ang (1-7) antiarrhythmic effects via sodium pump in ischaemic rat myocardium; leaves open human translation.
Does angiotensin (1-7) improve impulse conduction and membrane potential in ischaemic rat heart muscle?
Angiotensin (1-7) activates the sodium pump and re-establishes impulse conduction during ischaemia/reperfusion in rat hearts, providing a potential mechanism for its antiarrhythmic effects.
Walmor C. De Mello (2004) studied this question.
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