Key result
Endothelial lipase plasma levels were significantly higher in patients with carotid artery stenosis and a history of neurological impairment compared to asymptomatic patients (489.61 vs. 388.39 ng/ml, P=0.011).
Cross-Sectional (n=55)
No
Absolute Event Rate: 489.61% vs 388.39%
p-value: p=0.011
Increased endothelial lipase plasma levels are associated with a history of neurological impairment in patients with significant carotid artery stenosis, suggesting it may reflect susceptibility to cerebrovascular events.
May reflect cerebrovascular vulnerability in carotid stenosis; cross-sectional data leave its predictive value and therapeutic role open.
BACKGROUND: Endothelial lipase (EL) is a phospholipase expressed predominantly by vascular endothelial cells. The goal of the present study was to examine whether EL plasma levels in patients with carotid artery stenosis differ between those with previous history of neurological impairment and those without neurological symptoms. METHODS: EL plasma levels were measured by a competitive ELISA assay. RESULTS: EL plasma levels were significantly higher in the symptomatic, compared with the asymptomatic group (mean 489.61 ± 145 ng/ml (n = 31) vs. 388.39 ± 133 ng/ml (n = 24), t-test, P = 0.011). CONCLUSION: We concluded that increased EL plasma levels reflect the patients' overall susceptibility for cerebrovascular events.
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Monika Riederer (2012) conducted a cross-sectional in Carotid artery stenosis (n=55). History of neurological impairment vs. No history of neurological impairment (asymptomatic) was evaluated on Endothelial lipase (EL) plasma levels (p=0.011). Endothelial lipase plasma levels were significantly higher in patients with carotid artery stenosis and a history of neurological impairment compared to asymptomatic patients (489.61 vs. 388.39 ng/ml, P=0.011).
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