Key result
The Platelet Function Analyser (PFA)-100 is a highly sensitive screening tool for von Willebrand disease, with a normal result providing a 98% negative predictive value to rule out the condition.
Why the study?
Does the Platelet Function Analyser (PFA)-100 improve the screening and exclusion of von Willebrand disease in patients evaluated for bleeding disorders?
Population
Patients being evaluated for von Willebrand disease (VWD) or primary haemostasis disorders
Comparison
Platelet Function Analyser (PFA)-100 vs VWF ristocetin cofactor activity or skin…
Design
Editorial
Authors
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Supports PFA-100 as vWD screen with high NPV; leaves open need for prospective validation before routine adoption.
Does the Platelet Function Analyser (PFA)-100 improve the screening and exclusion of von Willebrand disease in patients evaluated for bleeding disorders?
The PFA-100 is a highly effective screening tool for excluding von Willebrand disease due to its 98% negative predictive value, though abnormal results require specific testing for definitive diagnosis.
Emmanuel J. Favaloro (2015) conducted a review in von Willebrand disease. Platelet Function Analyser (PFA)-100 was evaluated. The Platelet Function Analyser (PFA)-100 is a highly sensitive screening tool for von Willebrand disease, with a normal result providing a 98% negative predictive value to rule out the condition.
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