Key result
In youth with type 1 diabetes, dyslipidemia was present in 62.6% and associated with a higher frequency of microvascular complications compared to those without (27.2% vs 18.8%, P=0.005).
Why the study?
Cardiovascular risk and obesity are emerging as major health issues among individuals with type 1 diabetes.
Cross-Sectional (n=883)
Absolute Event Rate: 27.2% vs 18.8%
p-value: p=0.005
Youth with Type 1 diabetes exhibit a high prevalence of cardiovascular risk factors, including dyslipidemia and hypertension, which are significantly associated with poor metabolic control and obesity.
Dyslipidemia may signal higher microvascular risk in youth with type 1 diabetes; hypothesis-generating and requires prospective confirmation.
Cardiovascular risk and obesity are becoming major health issues among individuals with type 1 diabetes (T1D). The aim of this study was to evaluate cardiovascular risk factors and obesity in youth with T1D in Lithuania. Methods . 883 patients under 25 years of age with T1D for at least 6 months were investigated. Anthropometric parameters, blood pressure, and microvascular complications were evaluated, and the lipid profile and HbA1c were determined for all patients. Results . Study subjects’ mean HbA1c was 8.5±2%; 19.5% were overweight and 3.6% obese. Hypertension and dyslipidemia were diagnosed in 29.8% and 62.6% of participants, respectively. HbA1c concentration was directly related to levels of total cholesterol (r=0.274, p<0.001), LDL (r=0.271, p<0.001), and triglycerides (r=0.407, p<0.001) and inversely associated with levels of HDL (r=0.117, p=0.001). Prevalence of dyslipidemia increased with duration of diabetes (p<0.05). Hypertension was more prevalent in overweight and obese compared to normal-weight patients (40.6 and 65.6 vs. 25.6%, respectively, p<0.001). Frequency of microvascular complications was higher among patients with dyslipidemia (27.2 vs. 18.8%, p=0.005) and among those with hypertension (25.9 vs. 23.2%, p<0.001). Conclusion . The frequency of cardiovascular risk factors is high in youth with T1D and associated with diabetes duration, obesity, and metabolic control.
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Stankutė et al. (2019) conducted a cross-sectional in Type 1 diabetes (n=883). Dyslipidemia vs. Without dyslipidemia was evaluated on Microvascular complications (p=0.005). In youth with type 1 diabetes, dyslipidemia was present in 62.6% and associated with a higher frequency of microvascular complications compared to those without (27.2% vs 18.8%, P=0.005).
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