Key result
Aortic valve preservation in patients with bicuspid aortic valve and ascending aortic aneurysm significantly reduced left ventricular end-diastolic dimension from 6.10 cm to 5.67 cm (p<0.01) at 6 months.
Why the study?
Prosthetic aortic valve replacement effectively corrects hemodynamic issues in bicuspid aortic valve disease but carries important long-term drawbacks, particularly in younger patients.
Does aortic valve repair improve left ventricular dimensions and contractility in patients with bicuspid aortic valve disease and ascending aortic aneurysm?
Observational (n=40)
No
Does aortic valve repair improve left ventricular dimensions and contractility in patients with bicuspid aortic valve disease and ascending aortic aneurysm?
Absolute Event Rate: 5.67% vs 6.1%
p-value: p=<0.01
Aortic valve repair for bicuspid aortic valve with ascending aortic aneurysm is associated with significant improvements in left ventricular dimensions and low rates of significant regurgitation at 6 months.
Valve preservation yields acceptable early outcomes in BAV with TAA; leaves open need for larger comparative studies before practice change.
Background: Bicuspid aortic valve (BAV) is the most frequent congenital heart disease affecting 1% to 2% of the population, with thoracic aortic aneurysm (TAA) formation being its second most frequent complication after aortic valve dysfunction (stenosis or insufficiency). Aortic valve replacement (AVR) with mechanical or biologic prostheses has long been the procedure of choice. Although prosthetic AVR is effective in correcting the hemodynamic problem, there are important long-term drawbacks. These are particularly present in a younger patient population, such as the majority of individuals with a BAV. Patient and methods: 40 patients underwent aortic valve repair for bicuspid aortic valve disease with ascending aortic aneurysm in the period between June 2020 and February 2022 in Kasr Alainy hospitals. Results: All our patients showed significant improvement regarding left ventricular dimensions and contractility. Two patients had mild to moderate regurge and thirty eight patients had non-significant regurge in the six month follow up echo. One patient complicated by complete heart block required permanent pacemaker implantation, another two patients had postoperative high drainage required revision for bleeding. One patient died from ventilator associated pneumonia after prolonged mechanical ventilation due to disturbed conscious level.
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Allam et al. (2022) conducted an observational in Bicuspid aortic valve disease with ascending aortic aneurysm (n=40). Aortic valve preservation/repair vs. Preoperative baseline was evaluated on Left ventricular end-diastolic dimension (ED) at 6 months (p=<0.01). Aortic valve preservation in patients with bicuspid aortic valve and ascending aortic aneurysm significantly reduced left ventricular end-diastolic dimension from 6.10 cm to 5.67 cm (p<0.01) at 6 months.
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