January 1, 1997The Japanese Journal of PharmacologyOpen Access

Angiotensin II-Induced Pulmonary Edema in a Rabbit Model.

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Why the study?

Does losartan prevent angiotensin II-induced pulmonary edema in a rabbit model?

Population

Rabbit model

Comparison

Losartan administered before continuous infusion… vs No losartan (implied)

Design

Preclinical

Authors

TYTakatsugu YamamotoTeikyo University LWLiman WangFujian Medical University KSKazuro ShimakuraTokyo Medical and Dental University

Discussion

Member takes

Implication

Hypothesis-generating in rabbit model; clinical translation requires prospective human trials.

Structured PICO

Does losartan prevent angiotensin II-induced pulmonary edema in a rabbit model?

Population

Rabbit model

Intervention

Losartan (0.5 or 3.0 mg/kg) administered before continuous infusion of 150 microg/kg of angiotensin II

Comparator

No losartan (implied)

Outcome

Incidence of pulmonary edemasurrogate

Losartan prevents angiotensin II-induced pulmonary edema in a rabbit model, likely by reducing the pressor effect and afterload.

Cite This Study

Yamamoto et al. (1997) studied this question.

synapsesocial.com/papers/6a7b6f07684c0941cf3265ad https://doi.org/10.1254/jjp.73.33

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Angiotensin II-Induced Pulmonary Edema in a Rabbit Model.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II-Induced Pulmonary Edema in a Rabbit Model.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider