Key result
Persistent depressive symptoms in patients with coronary artery disease were associated with significantly greater declines in global cognition (mean MMSE score change -0.99) at 30 months.
Why the study?
Do persistent depressive symptoms increase the risk of cognitive decline in older patients with coronary artery disease?
Population
350 patients 60 years or older undergoing nonemergent catheterization without prior revascularization
Comparison
Persistent depressive symptoms vs No or baseline-only depressive symptoms
Design
Cohort
Follow-up
30 months
Authors
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May warrant cognitive monitoring in CAD patients with persistent depression; hypothesis-generating and requires prospective trials.
Cohort (n=350)
No
Do persistent depressive symptoms increase the risk of cognitive decline in older patients with coronary artery disease?
Mean Difference: -0.99
Persistent depressive symptoms in older patients with coronary artery disease are associated with a significantly greater risk of cognitive decline over 30 months.
Elizabeth Freiheit (2012) conducted a cohort in coronary artery disease (n=350). Persistent depressive symptoms vs. No or baseline-only depressive symptoms was evaluated on Mean change in domain and global cognitive scores from baseline to 30 months (MD -0.99). Persistent depressive symptoms in patients with coronary artery disease were associated with significantly greater declines in global cognition (mean MMSE score change -0.99) at 30 months.
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