Key result
Azilsartan attenuated both the increase in total body weight and adipose tissue weight compared with control in a rat model of high-fat diet-induced NAFLD, whereas aliskiren reduced adipogenesis only.
Why the study?
Does azilsartan, aliskiren, or their combination reduce body weight and adipogenesis in a rat model of high-fat diet-induced NAFLD?
Does azilsartan, aliskiren, or their combination reduce body weight and adipogenesis in a rat model of high-fat diet-induced NAFLD?
Answers are grounded in this paper and cite their sources.
In a rat model of high-fat diet-induced NAFLD, azilsartan attenuates both body weight gain and adipogenesis, whereas aliskiren reduces adipogenesis without affecting total body weight.
The renin-angiotensin system (RAS) plays an important role in the pathophysiology of many diseases including non-alcoholic fatty liver disease (NAFLD). This study aims to evaluate the effects of blocking RAS with azilsartan, aliskiren or their combination on the body weight and adipogenesis in rat’s model of NAFLD. Thirty-two rats were allocated into four groups and treated with either vehicle, azilsartan, aliskiren or their combination. All groups were maintained on high-fat diet for 60 days, and their body weights were monitored each 3 days. At the end of treatment all animals were authenticated and visceral adipose tissues obtained and weighed. Azilsartan attenuates both the increase in total body and adipose tissue weight compared with control, while azilsartan alone affects adipogenesis only. In conclusion, Administration of azilsartan attenuates adipogenesis and obesity in rat’s model of high-fat diet induced NAFLD, while aliskiren affects adipogenesis only.
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Utba et al. (2016) studied Non-alcoholic fatty liver disease (NAFLD) (n=32). Azilsartan, Aliskiren, or their combination vs. Vehicle (5% carboxymethyl cellulose) was evaluated on Adipose tissue weight to total body weight ratio (x 10^-2) (p=<0.05). Azilsartan attenuated both the increase in total body weight and adipose tissue weight compared with control in a rat model of high-fat diet-induced NAFLD, whereas aliskiren reduced adipogenesis only.
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