Why the study?
Does RAS inhibition with perindopril or irbesartan prevent liver inflammation and fibrosis in obese Zucker rats?
Population
Obese Zucker rats (animal model of metabolic syndrome)
Comparison
Perindopril or Irbesartan for 6 months vs Untreated obese Zucker rats, Amlodipine-treated…
Design
Preclinical
Follow-up
6 months
Authors
Loading...
No immediate clinical implications for NASH; leaves open whether RAS inhibition benefits translate from obese rat models to humans.
Does RAS inhibition with perindopril or irbesartan prevent liver inflammation and fibrosis in obese Zucker rats?
RAS inhibition with perindopril or irbesartan reduces hepatic inflammation and fibrosis in an animal model of metabolic syndrome, suggesting a potential therapeutic approach for NASH.
Toblli et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: