Key result
Perindopril treatment for 6 months significantly increased myocardial capillary density compared to untreated obese Zucker rats (1348 vs 436 capillaries/mm2, P<0.01).
Why the study?
Does perindopril improve myocardial angiogenesis in an animal model of obesity, hypertension, and NIDDM?
Population
30 10-week-old male rats: Obese Zucker rats and lean Zucker rats as an animal model of obesity…
Comparison
Perindopril 3 mg/kg daily by gavage for 6 months. vs Equal volume of vehicle for 6 months.
Design
Preclinical
Follow-up
6 months
Authors
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May enhance myocardial angiogenesis in metabolic syndrome rat models; leaves open human translation.
Does perindopril improve myocardial angiogenesis in an animal model of obesity, hypertension, and NIDDM?
Absolute Event Rate: 1348% vs 436%
p-value: p=<.01
In an animal model of metabolic syndrome, ACE inhibition with perindopril improved myocardial angiogenesis, reduced blood pressure, and improved the insulin/glucose ratio.
Jorge E. Toblli (2004) studied Obesity, hypertension, and non-insulin-dependent diabetes mellitus (animal model) (n=30). Perindopril vs. Vehicle was evaluated on Capillary density (capillaries/mm2) (p=<.01). Perindopril treatment for 6 months significantly increased myocardial capillary density compared to untreated obese Zucker rats (1348 vs 436 capillaries/mm2, P<0.01).
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