This paper describes the exploration of original tricyclic analogues of compound 1, previously identified as a lead compound during a Programme aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson's disease.We discovered several tricyclic [5,6,5]-imidazo[1,2-a]pyridines along with efficient ways of preparing them.These new heterocycles are novel starting points for original chemical series.
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Dominique Lesuisse (2021) studied this question.
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