Why the study?
Does ethanol ingestion affect plasma renin activity and aldosterone concentration in human volunteers?
Does ethanol ingestion affect plasma renin activity and aldosterone concentration in human volunteers?
Ethanol intoxication and subsequent hangover significantly stimulate the renin-aldosterone axis, likely driven by dehydration and sympathetic nervous system activation.
Ethanol may transiently disrupt RAAS in drinkers; hypothesis-generating for alcohol-related hypertension.
The renin-aldosterone system was studied in human volunteers during ethanol intoxication and hangover. Plasma renin activity increased more than 100%, when 1.5 - 2.3 g ethanol per kg body weight was ingested over a three hour period. During hangover the increase even exceeded 200%. Plasma aldosterone concentration decreased during ethanol intoxication, but increased greatly during hangover. It is suggested that the stimulation of the renin-aldosterone axis during ethanol intoxication and hangover is due to dehydration and increased activity of the sympathetic nervous system.
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Linkola et al. (1976) studied this question.
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