Key result
Most cases of hypertrophic cardiomyopathy and 20-50% of dilated cardiomyopathy are familial, demonstrating wide genetic and phenotypic heterogeneity.
Population
Patients with hypertrophic and dilated cardiomyopathies
Design
Review
Authors
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Supports family screening in HCM/DCM; extends genetic heterogeneity evidence while leaving genotype-phenotype predictions open.
This review summarizes the current knowledge on the causative genes, molecular mechanisms, and genotype-phenotype relations of hypertrophic and dilated cardiomyopathies.
Friedrich et al. (2012) conducted a review in Hypertrophic and dilated cardiomyopathy. Most cases of hypertrophic cardiomyopathy and 20-50% of dilated cardiomyopathy are familial, demonstrating wide genetic and phenotypic heterogeneity.
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