Why the study?
Does combining transcriptional and transductional targeting of AAV vectors improve cardiac gene transfer efficiency and specificity in adult mice?
Population
Adult mice
Comparison
Recombinant AAV vectors combining… vs AAV vectors with CMV promoter and standard AAV-2…
Design
Preclinical
Follow-up
3 weeks
Authors
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Preclinical cardiac AAV targeting advances in mice; leaves open translation to human gene therapy trials.
Does combining transcriptional and transductional targeting of AAV vectors improve cardiac gene transfer efficiency and specificity in adult mice?
Combining transcriptional targeting with the CMV(enh)/MLC1.5 promoter and modified AAV-2 capsids significantly improves cardiac-specific gene transfer while reducing liver transduction in mice.
Müller et al. (2006) studied this question.
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