Key result
Post-capillary pulmonary hypertension in heart failure was associated with a worse prognosis for all-cause death or hospitalization, especially for combined compared with isolated cases.
The application of the new ESC/ERS guidelines definition of post-capillary pulmonary hypertension identifies heart failure patients at increased risk of mortality and morbidity, particularly those with combined post-capillary pulmonary hypertension.
This commentary refers to ‘Post-capillary pulmonary hypertension in heart failure: impact of current definition in the PH-HF multicentre study’, by C. Fauvel et al., https://doi.org/10.1093/eurheartj/ehae467 and the discussion piece ‘Post-capillary pulmonary hypertension in heart failure: addressing statistical and methodological issues in research’, by G. Xiong, https://doi.org/10.1093/eurheartj/ehae812. We read with interest the letter from Dr Guang Xiong from Guangxi Medical University in China that reacted to our study recently published in the European Heart Journal,1 regarding the impact of the current ESC/ERS guidelines definition2 of post-capillary pulmonary hypertension (pcPH) in the French prospective and multicentre PH-HF registry. Among others, this study emphasized the impact of the new pcPH definitions (mean pulmonary artery pressyre lowered from 25–20 mmHg and pulmonary vascular resistance from 3 to 2 WU) in a cohort of patients with heart failure (HF), as well as the worse prognosis (all-cause death or hospitalization for HF) of HF patients with pcPH, that is even worse when patients have combined pcPH (CpcPH) compared with isolated pcPH (IpcPH).
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Fauvel et al. (2025) conducted a letter in Heart failure. Post-capillary pulmonary hypertension vs. Isolated post-capillary pulmonary hypertension was evaluated on All-cause death or hospitalization for heart failure. Post-capillary pulmonary hypertension in heart failure was associated with a worse prognosis for all-cause death or hospitalization, especially for combined compared with isolated cases.
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