Key result
Extra-platelet NO and NO+-containing drugs potently inhibit human platelet aggregation via both cGMP-dependent and cGMP-independent mechanisms.
This letter to the editor highlights prior evidence that NO donors inhibit platelet function via both cGMP-dependent and cGMP-independent mechanisms.
To the editor: Zhang and colleagues stated in their recent article[1][1] that it was unknown until their study whether NO donors inhibit platelet function by cGMP-dependent and cGMP-independent mechanisms. Yet we[2][2],[3][3] and others[4][4] reported several years ago that S -nitrosocysteine (CSNO
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Tsikas et al. (2012) studied this question. Extra-platelet NO and NO+-containing drugs potently inhibit human platelet aggregation via both cGMP-dependent and cGMP-independent mechanisms.
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