Key result
Two rare G6 rotavirus A strains (G6P[6] and G6P[9]) with unusual genotype constellations were identified in Italian children with diarrhoea, showing no evidence of zoonosis.
Observational
This study reports the first detection of rare G6P[6] and G6P[9] rotavirus A strains in peninsular Italy, with constellations previously associated with human cases.
Supports rotavirus strain surveillance in pediatric diarrhea; extends European data on rare human genotypes.
Two rare G6 rotavirus A (RVA) strains, designated as RVA/human-wt/ITA/CEC06/2011/G6P[6] and RVA/human-wt/ITA/PG05/2011/G6P[9], were identified in stool specimens from children hospitalized in Central Italy. After PCR genotyping, the samples CEC06 and PG05 gave G-UD-P[6] and G-UD-P[9] genotypes, respectively. To determine the G-type and to characterize further the two strains, sequencing of 8 of the 11 genomic segments was performed. CEC06 and PG05 strains were found to possess unusual genotype constellations: G6-P[6]-I2-A2-N2-T2-E2-H2 and G6-P[9]-I2-A3-N2-T3-E3-H3, respectively. This study reports the first detection of rare G6P[6] and G6P[9] RVA strains in peninsular Italy. Phylogenetic analysis of VP4 (VP8*), VP7, VP6, and NSP1-5 showed no evidence of zoonosis or inter-species reassortment, revealing for both strains constellations previously associated to human cases.
No takes yet. Share an insight, caveat, or question.
Ianiro et al. (2013) conducted an observational in Diarrhoea. Rare G6 rotavirus A strains (G6P[6] and G6P[9]) was evaluated on Genotype constellations and phylogenetic characteristics. Two rare G6 rotavirus A strains (G6P[6] and G6P[9]) with unusual genotype constellations were identified in Italian children with diarrhoea, showing no evidence of zoonosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: