Key result
An increased right ventricular E/E(r) ratio in patients with hypertrophic cardiomyopathy was associated with a higher risk of heart failure mortality (HR 1.6; 95% CI 1.1-2.4; P=0.03).
Why the study?
Do right ventricular diastolic function indices predict mortality in patients with hypertrophic cardiomyopathy?
Cohort (n=386)
Do right ventricular diastolic function indices predict mortality in patients with hypertrophic cardiomyopathy?
Hazard Ratio: 1.6 (95% CI 1.1–2.4)
p-value: p=0.03
Right ventricular restrictive physiology, assessed by echocardiography, is a significant predictor of heart failure and cardiovascular mortality in patients with hypertrophic cardiomyopathy.
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RV E/E(r) ratio may aid HCM risk stratification; hypothesis-generating and should not yet change practice.
Pagourelias et al. (2011) conducted a cohort in Hypertrophic cardiomyopathy (HCM) (n=386). Increased right ventricular E/E(r) ratio vs. Lower right ventricular E/E(r) ratio was evaluated on Mortality due to heart failure (HF) (HR 1.6, 95% CI 1.1-2.4, p=0.03). An increased right ventricular E/E(r) ratio in patients with hypertrophic cardiomyopathy was associated with a higher risk of heart failure mortality (HR 1.6; 95% CI 1.1-2.4; P=0.03).
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