Key result
Intramyocellular lipid was inversely associated with insulin sensitivity in healthy European American women (r = -0.54, P<0.05) but not in African American women (r = 0.16, P=0.424).
Population
57 healthy, normoglycemic women and girls, mean age 26 years, mean BMI 27.3 kg/m²; 32 African American, 25…
Design
Cross-sectional
Authors
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Ethnic differences in intramyocellular lipid–insulin sensitivity links may exist; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=57)
Effect estimate: r = -0.54 in European Americans
p-value: p=<0.05
Intramyocellular lipid is a significant determinant of insulin sensitivity in healthy European American women, but not in African American women, suggesting ethnic differences in metabolic risk pathways.
Lawrence et al. (2010) conducted a cross-sectional in Healthy (n=57). Intramyocellular lipid (IMCL) vs. African American vs European American ethnicity was evaluated on Association between intramyocellular lipid (IMCL) and insulin sensitivity (r = -0.54 in European Americans, p=<0.05). Intramyocellular lipid was inversely associated with insulin sensitivity in healthy European American women (r = -0.54, P<0.05) but not in African American women (r = 0.16, P=0.424).
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