Key result
Injection-molded non-isocyanate polyurethane (NIPU) prosthetic heart valves demonstrated ISO-compliant hydrodynamic performance comparable to clinical bioprostheses, with low thrombogenicity and no calcification at 8 weeks.
Non-isocyanate polyurethanes represent a promising, low-thrombogenic, and calcification-resistant sustainable biomaterial for the manufacturing of next-generation prosthetic heart valves.
NIPU elastomers may suit aortic valve leaflets; hypothesis-generating for in vivo durability and thrombogenicity trials.
, and used to produce aortic valves. PHU elastomers reinforced with a polyester mesh show mechanical properties similar to native valve leaflets. These NIPUs do not cause hemolysis. Interestingly, both platelet adhesion and contact activation-induced coagulation are strongly reduced on NIPU surfaces, indicating low thrombogenicity. Fibroblasts and endothelial cells maintain normal growth and shape after indirect contact with NIPUs. Fluid-structure interaction (FSI) allows modeling of the ideal valve design, with minimal shear stress on the leaflets. Injection-molded valves are tested in a pulse duplicator and show ISO-compliant hydrodynamic performance, comparable to clinically-used bioprostheses. Poly(tetrahydrofuran) (PTHF)-NIPU patches do not show any evidence of calcification over a period of 8 weeks. NIPUs are promising sustainable biomaterials for the manufacturing of improved prosthetic valves with low thrombogenicity.
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Melo et al. (2024) studied Prosthetic heart valve development. Green non-isocyanate polyurethane (NIPU) prosthetic heart valve vs. Clinically-used bioprostheses was evaluated on Hydrodynamic performance, thrombogenicity, and calcification. Injection-molded non-isocyanate polyurethane (NIPU) prosthetic heart valves demonstrated ISO-compliant hydrodynamic performance comparable to clinical bioprostheses, with low thrombogenicity and no calcification at 8 weeks.
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